Name: We've Got It Covered: RIFM's 2nd Annual Science Symposium
Start: 29/11/2023 01:00 PM +00:00
End: 29/11/2023 05:00 PM +00:00

Download a copy of An endpoint-specific framework for read-across analog selection for human health effects below

Endpoint-Specific Read-Across

Download a copy of While Tanimoto score is a useful tool for determining structural similarity, read-across analogs should not be based solely on this metric below

Tanimoto Score

Download a copy of&nbsp;The read-across approach for photosafety is a non-animal&nbsp;method that saves time -&nbsp;especially when applied to natural oils below

Photosafety Read-Across

Download a copy of Data-Driven Decision-making Using Advanced High-Throughput Environmental Risk Assessment of Fragrance Materials below

Environmental Framework

Download a copy of Developing the Internal Threshold for Toxicological Concern (iTTC): generating in vitro Caco-2 permeability and hepatocyte metabolism datasets needed for PBPK modeling below

Internal TTC

Download a copy of GARDskin dose-response for photo-sensitization below

GARDskin Dose-Response for Photo-sensitization

Download a copy of Evaluation and transferability of a New Approach Methodology to address photoallergy potential below

Photoallergy NAMs

Download a copy of Development of a database to derive inhalation TTC values for airborne compounds below

Inhalation TTC

Download a copy of Building fit-for-purpose NAMs for safety evaluation of inhalation exposure to compounds with complex physical and chemical properties below

Fit-for-purpose NAMs for Inhalation

Download IFRA NCS Botanical Definition &amp; Processing Method below

IFRA NCS Botanical Definition & Process Method

Download a copy of Pilot Study on Human Pluripotent Cell Model for Assessing Developmental Toxicity of Fragrance Materials below

Pluripotent Cell Model

Download a copy of Development of a chronic OTNE Speciies Sensitivity Distribution below

OTNE Species Sensitivity Distribution

Download a copy of Development and Application of Structural Activity Groups for Chemical Classification and Clustering as a Non-animal Method for Safety Assessment below

Structural Activity Groups

RIFM&rsquo;s scientists, working with critical collaborators across academia and industry, have published nearly two-dozen groundbreaking, peer-reviewed papers since 2020 that enhance our understanding of fragrance materials&rsquo; safety, providing insights and methodologies to help further avoid animal and human testing.
Notable recent publications include: a Criteria Document for Evaluating Natural Complex Substances, a paper detailing RIFM&rsquo;s use of chemical clustering and read-across (using data from one substance to help understand another similar substance), and The Genotoxicity Team published research papers confirming the use of the EpiDerm 3D Skin Assay, evaluating the effectiveness of the BlueScreen H.C., and a report comparing the BlueScreen results of 371 ingredients with in vitro and historical in vivo (animal) data.
Click through to our&nbsp;Fragrance Safety Resource Center (created in partnership with Elsevier) access all our groundbreaking published content for FREE.

Fragrance Safety Resource Center

RIFM membership means early and direct access to all available data and other resources to help you produce safe products and reach your company&rsquo;s goals. RIFM Member companies are recognized around the world for being progressive, actively promoting consumer safety and environmental stewardship by supporting RIFM's extensive program of testing and evaluating fragrance raw materials.
Benefits of being a RIFM Member include:
Access to Members-Only content and more
RIFM Membership affords a wealth of exclusive content, tools, events, and access to an expanded network of technical expertise.
The RIFM Database
Discounted rates to &nbsp;the largest worldwide website of information specific to flavor and fragrance materials &mdash; with over 6,000 ingredients and 80,000 associated human health and environmental studies, inventory information, and IFRA Standards.
Support for your scientific and regulatory compliance goals
Enjoy early awareness of scientific and regulatory issues, access to RIFM studies for regional registrations and assistance from RIFM staff scientists.

Become  RIFM Member

Scroll down to download copies of the documents associated with the Leveraging the RIFM Database: Utilizing NCS Information discussion

RIFM Database and NCS

Holger Moustakas

Jake Muldoon

Main Stage: Exploring Chemical Similarity

Isabelle Lee

Main Stage: New Approach Methodologies (NAMs) for Potency Assessment in Skin Sensitization

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and choose Breakout: Exploring Chemical Similarity</a>

Breakout: Exploring Chemical Similarity

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and choose Breakout: New Approach Methodologies (NAMs) for Potency Assessment in Skin Sensitization</a>

Maura Lavelle

Izzy Schember

Andreas Natsch

Andy Forreryd

Cindy Ryan

Shashi Donthamsetty

Breakout: New Approach Methodologies (NAMs) for Potency Assessment in Skin Sensitization

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and choose Leveraging the RIFM Database: Utilizing NCS Information</a>

Mary Mircovich

Kimberly Arencibia

Christen Sachse-Vasquez

Leveraging the RIFM Database: Utilizing NCS Information

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and choose Collaboration in Botanical Safety</a>

Yax Thakkar

Stefan Pfuhler

Collaboration in Botanical Safety

Aurelia Lapczynski

Main Stage: Next Generation of the RIFM Environmental Framework

Danielle Botelho

Anne Marie Api

Main Stage: Getting the Most Out of RIFM NCS Safety Assessments

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and choose Breakout: Next Generation of the RIFM Environmental Framework</a>

Breakout: Next Generation of the RIFM Environmental Framework

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and choose Breakout: Getting the Most out of NCS Safety Assessments</a>

Breakout: Getting The Most out of RIFM NCS Safety Assessments

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and click on Strategic New Approach Methodologies in Photo Safety</a>

Gretchen Ritacco

Chaitra Deodhar

Allison Hilberer

Strategic New Approach Methodologies in Photo Safety

<a href="https://events.hubilo.com/weve-got-it-covered/rooms">Click here to go to Rooms and click on Strategic New Approach Methodologies in Genotoxicity</a>

Agenda

Speakers.css-2zwi6c{margin:0;font-size:1.4rem;font-weight:500;line-height:1.5;color:#494949;font-family:'Poppins',sans-serif;margin-left:0.8rem;}22 Speakers

Gary Sullivan